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Penicillin G Benzathine Suspension for injection

What is this medicine?

PENICILLIN G BENZATHINE (pen i SILL in G BEN za thine) is a penicillin antibiotic. It is used to treat certain kinds of bacterial infections. It is also used to prevent a recurrence of rheumatic fever or Sydenham's chorea. It will not work for colds, flu, or other viral infections.

How should I use this medicine?

This medicine is for injection into a muscle. It is usually given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • dark urine

  • fever with headache, flushing

  • muscle cramps

  • pain or difficulty passing urine

  • red spots on the skin

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • seizures

  • unusual bleeding or bruising

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • dizziness

  • headache

  • pain where injected

  • stomach upset

What may interact with this medicine?

  • aspirin

  • birth control pills

  • diuretics

  • ethacrynic acid

  • indomethacin

  • methotrexate

  • phenylbutazone

  • probenecid

  • some antibiotics like chloramphenicol, erythromycin, sulfamethoxazole, tetracycline

  • typhoid vaccine

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • asthma

  • kidney disease

  • an unusual or allergic reaction to penicillin G benzathine, any penicillin or cephalosporin antibiotic, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

This medicine can interfere with some urine glucose tests. If you use such tests, talk with your health care professional.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Date Last Reviewed: 7/24/2009
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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