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Natalizumab (Murine) Solution for injection

What is this medicine?

NATALIZUMAB (na ta LIZ you mab) is used to treat relapsing multiple sclerosis. This drug is not a cure. It is also used to treat Crohn's disease.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in vision

  • chest pain

  • dark urine

  • depression, feelings of sadness

  • dizziness

  • general ill feeling or flu-like symptoms

  • irregular, missed, or painful menstrual periods

  • light-colored stools

  • loss of appetite, nausea

  • muscle weakness

  • problems with balance, talking, or walking

  • right upper belly pain

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • aches, pains

  • headache

  • stomach upset

  • tiredness

What may interact with this medicine?

  • azathioprine

  • cyclosporine

  • interferon

  • 6-mercaptopurine

  • methotrexate

  • steroid medicines like prednisone or cortisone

  • TNF-alpha inhibitors like adalimumab, etanercept, and infliximab

  • vaccines

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • immune system problems

  • progressive multifocal leukoencephalopathy (PML)

  • an unusual or allergic reaction to natalizumab, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Stay away from people who are sick. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself.

In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your doctor right away. If you cannot reach your doctor, get urgent medical care.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Date Last Reviewed: 2/6/2010
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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