What is Sjögren syndrome?
Sjögren syndrome is an autoimmune disorder. This means that the body’s own immune system attacks its own cells and tissues by mistake. In this case, it attacks the glands that produce moisture. It commonly causes dry skin, dry eyes, and dry mouth.
There are two types of Sjögren syndrome:
- Primary Sjögren. This is the term used when Sjögren syndrome appears by itself, without any other disease or illness. About half of cases are primary.
- Secondary Sjögren. This is when Sjögren syndrome occurs along with other autoimmune disorders, such as scleroderma, lupus, or rheumatoid arthritis. It accounts for half of all cases.
What causes Sjögren syndrome?
In Sjögren syndrome, the body’s white blood cells fight the glands that produce your body’s moisture. It is an autoimmune disorder.
What are the symptoms of Sjögren syndrome?
Symptoms of Sjögren syndrome can range from mild to severe—from discomfort to debilitating symptoms that can affect your overall quality of life. The two most common symptoms of Sjögren syndrome are dry eyes and dry mouth. From there, the disease can evolve into symptoms that affect the entire body.
Symptoms can include:
- Dry mouth, which can lead to trouble with talking, chewing, or swallowing
- Dry eyes that can have a gritty or burning feeling
- Dry, peeling lips
- Soreness or cracking on the tongue
- Dry or sore throat
- Tooth decay
- Dry skin
- Vaginal dryness
- Dry nose
- Changes in the ability to taste or smell
- Fatigue or tiredness
- Joint pain
- Digestive issues
What are the risk factors for Sjögren syndrome?
Sjögren syndrome is one of the most common autoimmune disorders in the U.S. It affects women more often than men. About half the time people will have Sjögren syndrome in addition to another autoimmune disorder such as rheumatoid arthritis, lupus, or scleroderma.
How is Sjögren syndrome diagnosed?
Sjögren syndrome is often hard to diagnose. That’s because the symptoms can overlap or look like those of other conditions, including chronic fatigue syndrome, fibromyalgia, lupus, rheumatoid arthritis, or even multiple sclerosis.
Rheumatologists use a point-based test to figure out if your symptoms might be related to Sjögren syndrome. The higher number of points you have, the more likely it is that you have the disease.
Along with physical symptoms, other tests that can help identify Sjögren syndrome include blood tests, eye tests and dental tests. Some of those tests include:
- ANA (Anti-Nuclear Antibody) blood test
- RF (Rheumatoid Factor) blood test
- SS-A and SS-B (Sjögren Syndrome) antibody blood markers
- ESR (Erythrocyte Sedimentation Rate) blood test
- IGs (Immunoglobulins) blood test
- Schirmer’s test to measure tear production
- Rose Bengal and Lissamine Green test to check the eyes for dryness
- Salivary flow to measure saliva production
- Salivary scintigraphy to measure salivary gland function
- Salivary gland biopsy
How is Sjögren syndrome treated?
There is no cure for Sjögren syndrome, but treatments can help relieve symptoms. The key is to work with a rheumatologist who can help you manage symptoms.
Common eye and mouth symptoms can often be treated with over-the-counter (OTC) eye and mouth drops. Your health care provider may be able to prescribe stronger formulas if OTC versions don’t help.
If your symptoms from Sjögren syndrome affect other areas of the body, you might find relief from some of the immunosuppressive drugs that are used to treat other autoimmune disorders. Pain medicine might be needed, too, depending on your symptoms.
Living with Sjögren syndrome
Besides remedies to help with dry eyes, dry mouth, and pain, diet can play a role in easing Sjögren syndrome symptoms. For example, avoiding alcohol and foods that are spicy, hard, crunchy, or acidic may help. All of these tend to make symptoms worse. Smooth, soft, and creamy foods like soups, casseroles, and pasta dishes are often good choices. Some people with Sjögren syndrome also have celiac disease and need to avoid gluten as well.
Experts think that omega-3 fatty acids may help relieve symptoms of dry eye. Clinical trials on using supplements are underway.
The Sjögren's Syndrome Foundation also suggests that you:
- Avoid medicines that might further dry your eyes, such as certain antihistamines and antidepressants. Talk with your health care provider about these choices.
- Don’t sit near air conditioning or heating vents. The dry air can also contribute to dry eyes.
- Use eye lubricants daily, even if you don’t have symptoms. Try sleeping with special eye gels that your health care provider can prescribe.
- Use warm compresses daily to soothe irritated eyelids.
- Brush your teeth after each meal. Floss daily to help prevent cavities caused by dry mouth.
- Get routine dental checkups.
- Avoid carbonated or acidic drinks.
- Chew sugarless gum, if needed, to help lubricate your mouth.
- Try using a room humidifier.
- Sjögren syndrome is an autoimmune disorder. It causes the body’s white blood cells fight the glands that produce your body’s moisture.
- Sjögren is one of the most common autoimmune disorders in the U.S. It is most common in women.
- The two most common symptoms of Sjögren syndrome are dry eyes and dry mouth.
- Sjögren syndrome is often hard to diagnose.
- Common eye and mouth symptoms can often be treated with over-the-counter (OTC) eye and mouth drops.
- There is no cure for Sjögren syndrome so it is important to work with a rheumatologist to manage symptoms.
- Besides remedies to help with dry eyes, dry mouth, and pain, diet can play a role in easing Sjögren syndrome symptoms.
Tips to help you get the most from a visit to your health care provider:
- Before your visit, write down questions you want answered.
- Bring someone with you to help you ask questions and remember what your provider tells you.
- At the visit, write down the names of new medicines, treatments, or tests, and any new instructions your provider gives you.
- If you have a follow-up appointment, write down the date, time, and purpose for that visit.
- Know how you can contact your provider if you have questions.
Online Medical Reviewer:
Sohrabi, Farrokh, MD
Online Medical Reviewer:
Ziegler, Olivia Walton, MS, PA-C
Date Last Reviewed:
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