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Amino Acids
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Serine

Other name(s):

a-amino-b-hydroxy-propionic acid

General Description

Phosphatidylserine is a fat-soluble phospholipid that occurs endogenously in humans. It is the most abundant phospholipid in the human brain and is important in many neuronal membrane functions.  Most of the body's phosphatidylserine comes of dietary sources.  

Unsubstantiated claims

Please note that this section reports on claims that have NOT yet been substantiated through scientific studies.

Serine is a natural moisturizing agent and is included in many skin-care preparations.

Clinical studies have shown that phosphatidyl serine improves attention, arousal, verbal fluency, and memory in aging people with cognitive deterioration.  The mechanism of action is unclear at this time.  More research is needed in this area.  

Recommended intake

Amino acids (AAs) are available as individual AAs or in proprietary AA combinations, as well as part of multi-vitamin formulas, proteins, and food supplements. The forms include tablets, fluids, and powders. However, adequate protein in the diet should provide a sufficient source of all amino acids.

There are no conditions that increase the nutritional requirements for serine.

Side effects, toxicity, and interactions

The use of a single amino acid supplement may lead to a negative nitrogen balance, decreasing the metabolic efficiency and increasing the workload of the kidneys. In children, taking single amino acid supplements may also harmfully affect growth parameters.

Always avoid taking individual amino acids in high dosage for prolonged periods.

Women who are pregnant or breastfeeding should not use serine supplements.

Additional information

Click here for a list of reputable websites with general information on nutrition.

Online Medical Reviewer: Wilkins, Joanna, R.D., C.D.
Date Last Reviewed: 2/19/2013
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