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Goserelin Acetate Implant

What is this medicine?

GOSERELIN (GOE se rel in) is similar to a hormone found in the body. It lowers the amount of sex hormones that the body makes. Men will have lower testosterone levels and women will have lower estrogen levels while taking this medicine. In men, this medicine is used to treat prostate cancer; the injection is either given once per month or once every 12 weeks. A once per month injection (only) is used to treat women with endometriosis, dysfunctional uterine bleeding, or advanced breast cancer.

How should I use this medicine?

This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting. Men receive this injection once every 4 weeks or once every 12 weeks. Women will only receive the once every 4 weeks injection.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • bone pain

  • breathing problems

  • changes in vision

  • chest pain

  • feeling faint or lightheaded, falls

  • fever, chills

  • pain, swelling, warmth in the leg

  • pain, tingling, numbness in the hands or feet

  • swelling of the ankles, feet, hands

  • trouble passing urine or change in the amount of urine

  • unusually high or low blood pressure

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance

  • changes in breast size in both males and females

  • changes in emotions or moods

  • headache

  • hot flashes

  • irritation at site where injected

  • loss of appetite

  • skin problems like acne, dry skin

  • vaginal dryness

What may interact with this medicine?

  • female hormones like estrogen

  • herbal or dietary supplements like black cohosh, chasteberry, or DHEA

  • male hormones like testosterone

  • prasterone

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions (some only apply to women):

  • diabetes

  • heart disease or previous heart attack

  • high blood pressure

  • high cholesterol

  • kidney disease

  • osteoporosis or low bone density

  • problems passing urine

  • spinal cord injury

  • stroke

  • tobacco smoker

  • an unusual or allergic reaction to goserelin, hormone therapy, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Your symptoms may appear to get worse during the first weeks of this therapy. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse after this time.

Your bones may get weaker if you take this medicine for a long time. If you smoke or frequently drink alcohol you may increase your risk of bone loss. A family history of osteoporosis, chronic use of drugs for seizures (convulsions), or corticosteroids can also increase your risk of bone loss. Talk to your doctor about how to keep your bones strong.

This medicine should stop regular monthly menstration in women. Tell your doctor if you continue to menstrate.

Women should not become pregnant while taking this medicine or for 12 weeks after stopping this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Men should inform their doctors if they wish to father a child. This medicine may lower sperm counts. Talk to your health care professional or pharmacist for more information.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Date Last Reviewed: 5/4/2010
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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