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Decongestants with Analgesics Oral tablet

What is this medicine?

IBUPROFEN; PSEUDOEPHEDRINE (eye BYOO proe fen; soo doe e FED rin) is a combination of a non-steroidal anti-inflammatory drug (NSAID) and a decongestant. It is used to treat the aches and pains, congestion, and fever of the common cold, flu, or sinus problems.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the package label. You can take it with or without food. If it upsets your stomach, take it with food. Try to not lie down for at least 10 minutes after you take the medicine. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • bloody, dark, tarry stools

  • breathing problems

  • chest pain

  • confused, agitated, or nervous

  • fast, irregular heartbeat

  • feeling faint or lightheaded, falls

  • hallucinations

  • high blood pressure

  • pain, tingling, numbness in the hands or feet

  • trouble passing urine or change in the amount of urine

  • unusual bleeding or bruising

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • headache

  • loss of appetite

  • nausea, stomach upset

  • restless or nervous

  • trouble sleeping

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • bromocriptine

  • cidofovir

  • cocaine

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • methotrexate

  • pemetrexed

  • stimulant medicines for attention disorders, weight loss, or to stay awake

This medicine may also interact with the following medications:

  • alcohol

  • alendronate

  • aspirin and aspirin-like medicines

  • cyclopropane

  • furazolidone

  • linezolid

  • ginkgo

  • mecamylamine

  • medicines for bladder problems

  • medicines for blood pressure, heart disease, irregular heart beat

  • medicines for chest pain like digoxin, nifedipine, verapamil

  • medicines for depression, anxiety, or psychotic disturbances

  • medicine for prostate

  • medicines for sleep during surgery

  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

  • other drugs for congestion, fever, inflammation, or pain

  • procarbazine

  • reserpine

  • steroid medicines like prednisone or cortisone

  • St. John's Wort

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:

  • bleeding problems

  • diabetes

  • heart disease or surgery

  • high blood pressure

  • kidney disease

  • not drinking fluids

  • severe vomiting or diarrhea

  • stomach ulcer or other problems

  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days

  • thyroid disease

  • an unusual or allergic reaction to ibuprofen, pseudoephedrine, other fever reducers or pain relievers, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. See your doctor if fever, pain, or nasal congestion gets worse or lasts more than 3 days.

If this medicine makes it hard for you to sleep, try taking the dose earlier in the day. If you still have trouble sleeping stop taking this medicine and see your doctor.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Date Last Reviewed: 5/5/2009
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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