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Brompheniramine Maleate, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride Oral syrup

What is this medicine?

BROMPHENIRAMINE; HYDROCODONE; PSEUDOEPHEDRINE (brome fen IR a meen; hye droe KOE done; soo doe e FED rin) is a combination of an antihistamine, a cough suppressant, and a decongestant. It is used to relieve cough, congestion, and runny nose. This medicine will not treat an infection.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medicine with food or milk if it upsets your stomach. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children less than 6 years old.

Patients over 60 years old may have a stronger reaction and need a smaller dose.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • anxiety or nervousness

  • breathing problems

  • changes in vision

  • dizzy or lightheaded

  • fast or irregular heartbeat

  • hallucinations

  • high blood pressure

  • seizure

  • trouble passing urine or change in the amount of urine

  • unusually weak

  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • drowsy or tired

  • dry mouth

  • headache

  • loss of appetite

  • stomach upset, nausea

  • trouble sleeping

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough and cold

  • barbiturates, like phenobarbital

  • heart medicines

  • mecamylamine

  • medicines for blood pressure

  • medicines for depression, anxiety, or psychotic disturbances

  • medicines for sleep

  • muscle relaxants

  • narcotic medicines (opiates) for pain

  • reserpine

  • some herbal or nutritional supplements

  • some medicines for Parkinson's disease

  • stimulant medicines for attention disorders, weight loss, or to stay awake

  • tramadol

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children. This drug can be abused. Keep this medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and is against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light.

Throw away any unused medicine after the expiration date. Discard unused medicine and used packaging carefully. Pets and children can be harmed if they find used or lost packages.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • asthma

  • diabetes

  • difficulty passing urine

  • drug abuse or addiction

  • glaucoma

  • high blood pressure

  • other chronic disease

  • stomach ulcer

  • taking an MAOI medicine like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • an unusual or allergic reaction to brompheniramine, hydrocodone, pseudoephedrine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

The medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Date Last Reviewed: 8/27/2012
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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